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Takako Yokozawa Selected Research

Oral Administration

9/2019Root Bark of Paeonia suffruticosa Extract and Its Component Methyl Gallate Possess Peroxynitrite Scavenging Activity and Anti-inflammatory Properties through NF-κB Inhibition in LPS-treated Mice.
12/2018Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling.
2/2016Allium hookeri root protects oxidative stress-induced inflammatory responses and β-cell damage in pancreas of streptozotocin-induced diabetic rats.
7/2009Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats.
3/2009The Chinese prescription Wen-Pi-Tang extract delays disease onset in amyotrophic lateral sclerosis model mice while attenuating the activation of glial cells in the spinal cord.
7/2008Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats.
10/2007Protective effect of heat-processed American ginseng against diabetic renal damage in rats.
10/2007Preventive effect of 20(S)-ginsenoside Rg3 against lipopolysaccharide-induced hepatic and renal injury in rats.
12/2006Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivo.
8/2006Protective effect of sun ginseng against diabetic renal damage.
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Takako Yokozawa Research Topics

Disease

69Body Weight (Weight, Body)
05/2021 - 09/2002
34Inflammation (Inflammations)
05/2021 - 12/2005
18Diabetic Nephropathies (Diabetic Nephropathy)
01/2020 - 02/2003
17Type 2 Diabetes Mellitus (MODY)
11/2020 - 04/2006
16Hyperglycemia
11/2011 - 08/2005
11Diabetes Complications
06/2015 - 08/2005
10Alzheimer Disease (Alzheimer's Disease)
05/2020 - 08/2009
9Renal Insufficiency (Renal Failure)
01/2012 - 04/2003
7Hypertension (High Blood Pressure)
11/2020 - 11/2006
7Dyslipidemias (Dyslipidemia)
11/2020 - 10/2009
7Diabetes Mellitus
07/2016 - 09/2002
7Hyperlipidemias (Hyperlipidemia)
06/2014 - 01/2008
7Chronic Kidney Failure (Chronic Renal Failure)
01/2010 - 04/2004
7Ischemia
08/2005 - 09/2002
6Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2020 - 09/2007
6Fibrosis (Cirrhosis)
09/2013 - 12/2005
6Proteinuria
03/2007 - 02/2003
5Acute Kidney Injury (Acute Renal Failure)
09/2019 - 12/2004
5Memory Disorders (Memory Loss)
06/2019 - 02/2010
5Neoplasms (Cancer)
01/2019 - 12/2007
4Hypercholesterolemia
03/2020 - 12/2005
4Insulin Resistance
08/2018 - 01/2014
4Sclerosis
01/2012 - 01/2004
3Melanoma (Melanoma, Malignant)
04/2015 - 11/2007
3Cardiovascular Diseases (Cardiovascular Disease)
06/2010 - 10/2009
2Chronic Renal Insufficiency
11/2020 - 01/2010
2Obesity
03/2020 - 08/2018

Drug/Important Bio-Agent (IBA)

38Proteins (Proteins, Gene)FDA Link
05/2020 - 09/2002
23Kangen-karyuIBA
11/2020 - 07/2004
23Glucose (Dextrose)FDA LinkGeneric
11/2017 - 09/2002
18AntioxidantsIBA
09/2019 - 10/2002
15Streptozocin (Streptozotocin)FDA Link
12/2018 - 09/2002
13NF-kappa B (NF-kB)IBA
09/2019 - 08/2006
13PolyphenolsIBA
12/2018 - 04/2003
12oligonolIBA
01/2019 - 10/2010
10Advanced Glycation End ProductsIBA
03/2017 - 06/2004
10hachimijiogan (TJ 7)IBA
07/2013 - 01/2004
10CholesterolIBA
01/2012 - 01/2004
9LipidsIBA
06/2014 - 01/2004
8CreatinineIBA
01/2019 - 12/2002
8Glycoproteins (Glycoprotein)IBA
09/2008 - 04/2003
7EnzymesIBA
05/2020 - 04/2003
7Dihydrotachysterol (AT 10)IBA
12/2018 - 12/2004
7LipopolysaccharidesIBA
01/2017 - 09/2002
77-O-galloyl-D-sedoheptuloseIBA
06/2016 - 08/2010
6Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
05/2017 - 08/2006
6Cyclooxygenase 2 (Cyclooxygenase-2)IBA
05/2017 - 08/2006
6Reactive Oxygen Species (Oxygen Radicals)IBA
01/2014 - 04/2003
6Urea (Carbamide)FDA LinkGeneric
01/2010 - 12/2002
6NitrogenIBA
01/2010 - 12/2002
5NADP (NADPH)IBA
05/2017 - 01/2012
53-nitrotyrosineIBA
08/2016 - 09/2002
5morronisideIBA
06/2016 - 07/2008
5IridoidsIBA
06/2015 - 07/2007
5GlycosidesIBA
06/2015 - 07/2007
5wen-pi-tangIBA
03/2009 - 12/2002
4Amyloid (Amyloid Fibrils)IBA
05/2020 - 07/2014
4Cisplatin (Platino)FDA LinkGeneric
01/2019 - 07/2013
4Insulin (Novolin)FDA Link
08/2018 - 04/2006
4NADPH Oxidases (NAD(P)H oxidase)IBA
05/2017 - 01/2012
4loganinIBA
06/2016 - 12/2010
4Triglycerides (Triacylglycerol)IBA
01/2012 - 01/2004
4FructoseIBA
02/2010 - 09/2007
4Indicators and Reagents (Reagents)IBA
01/2010 - 09/2002
4gamma-Aminobutyric Acid (GABA)IBA
04/2007 - 12/2004
4Blood Glucose (Blood Sugar)IBA
03/2007 - 01/2004
4TeaIBA
10/2006 - 04/2003
3Cholinesterases (Cholinesterase)IBA
05/2020 - 03/2016
3Cholinergic Agents (Cholinergics)IBA
06/2019 - 01/2011
3Caspase 3 (Caspase-3)IBA
01/2019 - 01/2012
3Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA
12/2017 - 03/2016
3JNK Mitogen-Activated Protein KinasesIBA
01/2017 - 01/2012
3Peroxynitrous Acid (Peroxynitrite)IBA
08/2016 - 09/2002
3Melanins (Melanin)IBA
04/2015 - 11/2007
3Monophenol Monooxygenase (Tyrosinase)IBA
04/2015 - 11/2007
3Peroxisome Proliferator-Activated Receptors (PPAR)IBA
06/2014 - 04/2009
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2012 - 09/2010
3Fibronectins (Fibronectin)IBA
07/2011 - 09/2005
3ethyl acetateIBA
02/2010 - 06/2007
3Hypoglycemic Agents (Hypoglycemics)IBA
10/2009 - 10/2006
3gallocatechol (epigallocatechin)IBA
08/2009 - 04/2004
3proanthocyanidinIBA
09/2008 - 08/2005
3Serum AlbuminIBA
07/2008 - 01/2004
3Superoxides (Superoxide)IBA
12/2004 - 10/2002
2Glycogen Synthase KinasesIBA
05/2020 - 11/2018
2Therapeutic UsesIBA
01/2020 - 01/2019
2lithospermate BIBA
08/2018 - 05/2017
2Oxidoreductases (Dehydrogenase)IBA
05/2017 - 01/2012
2Interleukin-6 (Interleukin 6)IBA
01/2017 - 06/2015
2Transcription Factor AP-1 (Transcription Factor AP 1)IBA
01/2017 - 06/2015
2GlucosidasesIBA
03/2016 - 01/2011
2Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
06/2015 - 01/2012
2astaxanthine (astaxanthin)IBA
03/2015 - 10/2009
2Proanthocyanidins (Procyanidins)IBA
02/2015 - 09/2008
2Transcription Factors (Transcription Factor)IBA
02/2015 - 06/2010

Therapy/Procedure

23Oral Administration
09/2019 - 09/2002
9Nephrectomy
04/2007 - 01/2004
3Intraperitoneal Injections
01/2019 - 01/2017
2Chinese Traditional Medicine (Traditional Chinese Medicine)
03/2020 - 01/2020
2Therapeutics
01/2020 - 06/2005